Robert C Glen Selected Research

Apelin Receptors

6/2020	Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.
1/2020	The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo.
1/2019	A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension.
11/2017	Pharmacological targeting of apelin impairs glioblastoma growth.
4/2015	Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist.
6/2011	Discovery of a competitive apelin receptor (APJ) antagonist.

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Robert C Glen Research Topics

Disease

5	Pulmonary Arterial Hypertension 06/2020 - 01/2016
4	Neoplasms (Cancer) 11/2017 - 01/2013
2	Heart Failure 06/2020 - 04/2015
2	Infections 01/2018 - 11/2015
1	Vascular Diseases (Vascular Disease) 11/2021
1	Familial encephalopathy with neuroserpin inclusion bodies 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021
1	Dementia (Dementias) 01/2021
1	Epilepsy (Aura) 01/2021
1	Obesity 10/2020
1	Chronic Disease (Chronic Diseases) 01/2020
1	Hypertrophy 01/2019
1	Glioblastoma (Glioblastoma Multiforme) 11/2017
1	Vascular Remodeling 03/2017
1	Hypoxia (Hypoxemia) 03/2017
1	Right Ventricular Hypertrophy 03/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Anxiety Disorders (Anxiety Disorder) 11/2016
1	Pain (Aches) 11/2016
1	Pulmonary Hypertension 04/2015
1	Metabolic Diseases (Metabolic Disease) 06/2011

Drug/Important Bio-Agent (IBA)

7	ApelinIBA 06/2020 - 04/2015
6	Apelin ReceptorsIBA 06/2020 - 06/2011
5	Peptides (Polypeptides)IBA 06/2020 - 03/2017
2	LipidsIBA 10/2020 - 01/2013
2	CMF-019IBA 01/2020 - 01/2016
2	MonocrotalineIBA 01/2019 - 03/2017
1	MethylaminesIBA 11/2021
1	Carnitine (L-Carnitine)FDA LinkGeneric 11/2021
1	Choline (Choline Chloride)IBA 11/2021
1	NeuroserpinIBA 01/2021
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2021
1	Triglycerides (Triacylglycerol)IBA 10/2020
1	GTP-Binding Proteins (G-Protein)IBA 01/2020
1	PropionatesIBA 01/2018
1	NexusIBA 11/2017
1	PlasticsIBA 11/2017
1	LigandsIBA 11/2016
1	Butyric Acid (Butanoic Acid)IBA 11/2016
1	Vasodilator Agents (Vasodilators)IBA 04/2015
1	Oxidoreductases (Dehydrogenase)IBA 04/2013
1	Hormones (Hormone)IBA 04/2013
1	Estrogen ReceptorsIBA 04/2013
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 03/2013
1	Amino Acids FDA Link 01/2013
1	Biological ProductsIBA 01/2013
1	NAD (NADH)IBA 01/2013
1	Nucleic AcidsIBA 01/2013
1	Proteins (Proteins, Gene)FDA Link 01/2013
1	Pharmaceutical PreparationsIBA 01/2013
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2011

Therapy/Procedure

3	Therapeutics 01/2017 - 01/2013